331749-88-3
Chemical Structure
Centmitor-1
Synonym(s): Cent-1
- CAS No.: 331749-88-3
- Formula:C22H16BrN3O3
- Molecular Weight:450.28
IUPAC Name: (E)-N'-(3-bromo-4-hydroxybenzylidene)-2-(9-oxoacridin-10(9H)-yl)acetohydrazide
InChIKey: JOGAHIHJROVAFZ-WYMPLXKRSA-N
SMILES: O=C1C2=C(N(CC(N/N=C/C3=CC=C(C(Br)=C3)O)=O)C4=C1C=CC=C4)C=CC=C2
Biological Activity: Centmitor-1 (Cent-1) is a mitotic arrest inducer. Centmitor-1 modulates microtubule plus-ends and reduced microtubule dynamics. In cells, Centmitor-1 causes mitotic arrest characterized by chromosome alignment defects, multipolar spindles, centrosome fragmentation, and activated spindle assembly checkpoint[1].
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Centmitor-1 | Centmitor-1 (Cent-1) is a mitotic arrest inducer. Centmitor-1 modulates microtubule plus-ends and reduced microtubule dynamics. In cells, Centmitor-1 causes mitotic arrest characterized by chromosome alignment defects, multipolar spindles, centrosome fragmentation, and activated spindle assembly checkpoint. | |||||||||||||||||||||
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Keywords
