335063-97-3
335063-97-3
Chemical Structure
NHE-1-IN-1
- CAS No.: 335063-97-3
- Formula:C21H24FN5O
- Molecular Weight:381.46
IUPAC Name: 5-(4-fluoro-3-methylphenyl)-2-methoxy-4-(4-(4-methyl-1H-imidazol-5-yl)piperidin-1-yl)pyrimidine
InChIKey: QFLBHMYSGGBXPC-UHFFFAOYSA-N
SMILES: FC1=CC=C(C=C1C)C=2C=NC(=NC2N3CCC(C=4NC=NC4C)CC3)OC
Biological Activity: NHE-1-IN-1 is a non-acylguanidine NHE-1 inhibitor with IC50 values of 0.0065 μM and 9 μM for human NHE-1 and NHE-2, respectively. NHE-1-IN-1 inhibits NHE-1 function by suppressing NHE-1-mediated Na+-dependent intracellular pH recovery after acidification. NHE-1-IN-1 can be used for research on NHE-1-related cardiovascular regulation[1].
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NHE-1-IN-1 | NHE-1-IN-1 is a non-acylguanidine NHE-1 inhibitor with IC50 values of 0.0065 μM and 9 μM for human NHE-1 and NHE-2, respectively. NHE-1-IN-1 inhibits NHE-1 function by suppressing NHE-1-mediated Na+-dependent intracellular pH recovery after acidification. NHE-1-IN-1 can be used for research on NHE-1-related cardiovascular regulation. | |||||||||||||||||||||
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