339096-59-2
Chemical Structure
SARS-CoV-2 Mpro/TMPRSS2/Furin-IN-1
- CAS No.: 339096-59-2
- Formula:C19H18N14O2
- Molecular Weight:474.44
InChIKey: RKERUHFQUMGLTH-AGGYBRLQSA-N
SMILES: N=C(C1=NON=C1NCNC2=NON=C2C(N/N=C/C3=CC=NC=C3)=N)N/N=C/C4=CC=NC=C4
Biological Activity: SARS-CoV-2 Mpro/TMPRSS2/Furin-IN-1 is a multi-target inhibitor targeting SARS‑CoV‑2 Mpro, human TMPRSS2, and furin. SARS-CoV-2 Mpro/TMPRSS2/Furin-IN-1 inhibits SARS-CoV-2 Mpro (IC50 = 0.013 µM), human TMPRSS2 (IC50 = 0.05 µM), and human furin (IC50 = 0.09 µM). SARS-CoV-2 Mpro/TMPRSS2/Furin-IN-1 blocks polyprotein cleavage as well as TMPRSS2/furin-mediated spike protein activation and viral entry, thereby inhibiting SARS-CoV-2 replication in cells. Loading SARS-CoV-2 Mpro/TMPRSS2/Furin-IN-1 onto zinc oxide nanoparticles enhances its antiviral potency. SARS-CoV-2 Mpro/TMPRSS2/Furin-IN-1 can be used for research related to SARS‑CoV‑2 coronavirus infection[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
SARS-CoV-2 Mpro/TMPRSS2/Furin-IN-1 | SARS-CoV-2 Mpro/TMPRSS2/Furin-IN-1 is a multi-target inhibitor targeting SARS‑CoV‑2 Mpro, human TMPRSS2, and furin. SARS-CoV-2 Mpro/TMPRSS2/Furin-IN-1 inhibits SARS-CoV-2 Mpro (IC50 = 0.013 µM), human TMPRSS2 (IC50 = 0.05 µM), and human furin (IC50 = 0.09 µM). SARS-CoV-2 Mpro/TMPRSS2/Furin-IN-1 blocks polyprotein cleavage as well as TMPRSS2/furin-mediated spike protein activation and viral entry, thereby inhibiting SARS-CoV-2 replication in cells. Loading SARS-CoV-2 Mpro/TMPRSS2/Furin-IN-1 onto zinc oxide nanoparticles enhances its antiviral potency. SARS-CoV-2 Mpro/TMPRSS2/Furin-IN-1 can be used for research related to SARS‑CoV‑2 coronavirus infection. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
