342419-10-7
342419-10-7
Chemical Structure
CVT-2759 analog
- CAS No.: 342419-10-7
- Formula:C17H24N6O6
- Molecular Weight:408.41
IUPAC Name: ((2R,3S,4R,5R)-3,4-dihydroxy-5-(6-(((R)-tetrahydrofuran-3-yl)amino)-9H-purin-9-yl)tetrahydrofuran-2-yl)methyl ethylcarbamate
InChIKey: OBAAIGREYDUOHX-ZGOQAQPGSA-N
SMILES: O[C@H]1[C@@H](O)[C@H](N2C=NC3=C2N=CN=C3N[C@H]4COCC4)O[C@@H]1COC(NCC)=O
Biological Activity: CVT-2759 analog (compound 15) is a partial agonist of A1 adenosine receptor (Ki=167 nM) and can be used for the study of cardiac arrhythmias[1].
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CVT-2759 analog | CVT-2759 analog (compound 15) is a partial agonist of A1 adenosine receptor (Ki=167 nM) and can be used for the study of cardiac arrhythmias. | |||||||||||||||||||||
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References
- [1]. Palle VP, et al. Affinity and intrinsic efficacy (IE) of 5'-carbamoyl adenosine analogues for the A1 adenosine receptor--efforts towards the discovery of a chronic ventricular rate control agent for the treatment of atrial fibrillation (AF). Bioorg Med Chem Lett. 2004 Jan 19;14(2):535-9. [Content Brief]
