3430-21-5
3430-21-5
Chemical Structure
5-Bromo-3-methylpyridin-2-amine
- CAS No.: 3430-21-5
- Formula:C6H7BrN2
- Molecular Weight:187.04
IUPAC Name: 5-bromo-3-methylpyridin-2-amine
InChIKey: KBLGGRWUEVCNPY-UHFFFAOYSA-N
SMILES: NC(C(C)=C1)=NC=C1Br
Biological Activity: 5-Bromo-3-methylpyridin-2-amine is a synthetic intermediate. 5-Bromo-3-methylpyridin-2-amine can be used in the synthesis of the ATX inhibitor GLPG1690 (HY-101772) and IRAK4 inhibitors[1][2].
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5-Bromo-3-methylpyridin-2-amine | 5-Bromo-3-methylpyridin-2-amine is a synthetic intermediate. 5-Bromo-3-methylpyridin-2-amine can be used in the synthesis of the ATX inhibitor GLPG1690 (HY-101772) and IRAK4 inhibitors. | |||||||||||||||||||||
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References
- [1]. Matralis AN, et al. Development and therapeutic potential of autotaxin small molecule inhibitors: From bench to advanced clinical trials. Medicinal research reviews. 2019 May;39(3):976-1013.
- [2]. Evans R, et al. The Discovery of 7-Isopropoxy-2-(1-methyl-2-oxabicyclo [2.1. 1] hexan-4-yl)-N-(6-methylpyrazolo [1, 5-a] pyrimidin-3-yl) imidazo [1, 2-a] pyrimidine-6-carboxamide (BIO-7488), a Potent, Selective, and CNS-Penetrant IRAK4 Inhibitor for the Treatment of Ischemic Stroke. Journal of Medicinal Chemistry. 2024 Mar 12;67(6):4676-90.
