344607-69-8
344607-69-8
Chemical Structure
BMS-210285
- CAS No.: 344607-69-8
- Formula:C24H25ClF2N2O5S
- Molecular Weight:526.98
IUPAC Name: N-(5-((R)-2-(((R)-2-(3-chlorophenyl)-1-(4-(difluoromethoxy)phenyl)ethyl)amino)-1-hydroxyethyl)-2-hydroxyphenyl)methanesulfonamide
InChIKey: DSEGFUSAJVUFLK-OFNKIYASSA-N
SMILES: CS(=O)(NC1=CC([C@@H](O)CN[C@@H](C2=CC=C(OC(F)F)C=C2)CC3=CC=CC(Cl)=C3)=CC=C1O)=O
Biological Activity: BMS-210285 is a highly selective agonist for the 3 receptor. BMS-210285 has a Ki of 9 nM at the human 3-adrenoceptor. BMS-210285 possesses a 3 intrinsic activity of 83% relative to isoproterenol. BMS-210285 can be studied for obesity and type 2 diabetes research[1][2].
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BMS-210285 | BMS-210285 is a highly selective agonist for the 3 receptor. BMS-210285 has a Ki of 9 nM at the human 3-adrenoceptor. BMS-210285 possesses a 3 intrinsic activity of 83% relative to isoproterenol. BMS-210285 can be studied for obesity and type 2 diabetes research. | |||||||||||||||||||||
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References
- [1]. Hu, B., & Jennings, L. L. (2003). Orally bioavailable beta 3-adrenergic receptor agonists as potential therapeutic agents for obesity and type-II diabetes. Progress in medicinal chemistry, 41, 167-194. [Content Brief]
- [2]. Kordik, C. P., & Reitz, A. B. (1999). Pharmacological treatment of obesity: therapeutic strategies. Journal of medicinal chemistry, 42(2), 181-201. [Content Brief]
