34696-50-9
Chemical Structure
Deacetylsclerotiorin
- CAS No.: 34696-50-9
- Formula:C19H21ClO4
- Molecular Weight:348.82
IUPAC Name: (R)-5-chloro-3-((S,1E,3E)-3,5-dimethylhepta-1,3-dien-1-yl)-7-hydroxy-7-methyl-6H-isochromene-6,8(7H)-dione
InChIKey: SBUBEONHXLXYBK-GFYBKASGSA-N
SMILES: O=C1[C@](O)(C(C2=COC(/C=C/C(C)=C/[C@H](CC)C)=CC2=C1Cl)=O)C
Biological Activity: Deacetylsclerotiorin is a secondary metabolite of chloramphenicol isolated from the fungus Bartalinia robillardoides strain LF550. Deacetylsclerotiorin has significant inhibitory effects on Candida albicans (IC50=24 μM), Trichophyton rubrum (IC50=2.83 μM) and Septoria tritici (IC50=7..45 μM). In addition, Deacetylsclerotiorin also exhibits inhibitory effects on the enzyme phosphodiesterase 4 (PDE4) (IC50=2.8 μM)[1].
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Deacetylsclerotiorin | Deacetylsclerotiorin is a secondary metabolite of chloramphenicol isolated from the fungus Bartalinia robillardoides strain LF550. Deacetylsclerotiorin has significant inhibitory effects on Candida albicans (IC50=24 μM), Trichophyton rubrum (IC50=2.83 μM) and Septoria tritici (IC50=7..45 μM). In addition, Deacetylsclerotiorin also exhibits inhibitory effects on the enzyme phosphodiesterase 4 (PDE4) (IC50=2.8 μM). | |||||||||||||||||||||
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