349-58-6
349-58-6
Chemical Structure
KG-655
- CAS No.: 349-58-6
- Formula:C8H4F6O
- Molecular Weight:230.11
IUPAC Name: 3,5-bis(trifluoromethyl)phenol
InChIKey: ODSXJQYJADZFJX-UHFFFAOYSA-N
SMILES: OC1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1
Biological Activity: KG-655 is a ligand that specifically binds to the ARNT PAS-B domain. KG-655 binds to the internal cavity of ARNT PAS-B to restrict its variable folded conformation, disrupts the interaction between ARNT PAS-B and the transcriptional coactivator TACC3, and promotes the homodimerization of ARNT PAS-B. KG-655 is widely applicable to cancer-related research[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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KG-655 | 99.06% | KG-655 is a ligand that specifically binds to the ARNT PAS-B domain. KG-655 binds to the internal cavity of ARNT PAS-B to restrict its variable folded conformation, disrupts the interaction between ARNT PAS-B and the transcriptional coactivator TACC3, and promotes the homodimerization of ARNT PAS-B. KG-655 is widely applicable to cancer-related research. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.91
HY-750881-Bromo-3,5-bis(trifluoromethyl)benzene -
Similarity Score 0.91
HY-W0087843,5-Di(trifluoromethyl)aniline -
Similarity Score 0.84
HY-W014230R1,4-Bis(trifluoromethyl)benzene (Standard) -
Similarity Score 0.72
HY-W0146324-Trifluoromethylsalicylic acid -
Similarity Score 0.72
HY-W014632S4-Trifluoromethylsalicylic acid-13C6 -
Similarity Score 0.72
HY-W014566R4-Nitro-3-(trifluoromethyl)phenol (Standard) -
Similarity Score 0.70
HY-778225-Amino-2-chlorobenzotrifluoride -
Similarity Score 0.70
HY-328544-Bromo-3-(trifluoromethyl)aniline -
Similarity Score 0.70
HY-329023-(Trifluoromethyl)phenylboronic acid -
Explore the MedChemAI to find more analogs
References
- [1]. Xu X, Closson J D, et al. Identification of small-molecule ligand-binding sites on and in the ARNT PAS-B domain[J]. Journal of Biological Chemistry, 2024, 300(9): 107606.
- [2]. Gagné D, et al. Use of high pressure NMR spectroscopy to rapidly identify proteins with internal ligand-binding voids[J]. bioRxiv, 2025: 2020.08. 25.267195.
