349-58-6
349-58-6
Chemical Structure
KG-655
- CAS No.: 349-58-6
- Formula:C8H4F6O
- Molecular Weight:230.11
IUPAC Name: 3,5-bis(trifluoromethyl)phenol
InChIKey: ODSXJQYJADZFJX-UHFFFAOYSA-N
SMILES: OC1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1
Biological Activity: KG-655 is a ligand that specifically binds to the ARNT PAS-B domain. KG-655 binds to the internal cavity of ARNT PAS-B to restrict its variable folded conformation, disrupts the interaction between ARNT PAS-B and the transcriptional coactivator TACC3, and promotes the homodimerization of ARNT PAS-B. KG-655 is widely applicable to cancer-related research[1][2].
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KG-655 | 99.06% | KG-655 is a ligand that specifically binds to the ARNT PAS-B domain. KG-655 binds to the internal cavity of ARNT PAS-B to restrict its variable folded conformation, disrupts the interaction between ARNT PAS-B and the transcriptional coactivator TACC3, and promotes the homodimerization of ARNT PAS-B. KG-655 is widely applicable to cancer-related research. | ||||||||||||||||||||
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References
- [1]. Xu X, Closson J D, et al. Identification of small-molecule ligand-binding sites on and in the ARNT PAS-B domain[J]. Journal of Biological Chemistry, 2024, 300(9): 107606.
- [2]. Gagné D, et al. Use of high pressure NMR spectroscopy to rapidly identify proteins with internal ligand-binding voids[J]. bioRxiv, 2025: 2020.08. 25.267195.
Keywords
