350992-10-8
350992-10-8
Chemical Structure
Bifeprunox
- CAS No.: 350992-10-8
- Formula:C24H23N3O2
- Molecular Weight:385.46
IUPAC Name: 7-(4-([1,1'-biphenyl]-3-ylmethyl)piperazin-1-yl)benzo[d]oxazol-2(3H)-one
InChIKey: CYGODHVAJQTCBG-UHFFFAOYSA-N
SMILES: O=C1OC2=C(N3CCN(CC4=CC=CC(C5=CC=CC=C5)=C4)CC3)C=CC=C2N1
Biological Activity: Bifeprunox is a potent dopamine D2-like and 5-HT1A receptor partial agonist with pKis of 7.19 and 8.83 for cortex 5-HT1A and striatum D2, and a pEC50 of 6.37 for hippocampus 5-HT1A, respectively. Bifeprunox is an antipsychotic for the research of schizophrenia[1][2].
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Bifeprunox | Bifeprunox is a potent dopamine D2-like and 5-HT1A receptor partial agonist with pKis of 7.19 and 8.83 for cortex 5-HT1A and striatum D2, and a pEC50 of 6.37 for hippocampus 5-HT1A, respectively. Bifeprunox is an antipsychotic for the research of schizophrenia. | |||||||||||||||||||||
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References
- [1]. Newman-Tancredi A, et al. Novel antipsychotics activate recombinant human and native rat serotonin 5-HT1A receptors: affinity, efficacy and potential implications for treatment of schizophrenia. Int J Neuropsychopharmacol. 2005 Sep;8(3):341-56. [Content Brief]
- [2]. Bruins Slot LA, et al. Effects of antipsychotics and reference monoaminergic ligands on marble burying behavior in mice. Behav Pharmacol. 2008 Mar;19(2):145-52. [Content Brief]
Keywords
