352697-38-2
Chemical Structure
TL-310
- CAS No.: 352697-38-2
- Formula:C45H55NO16
- Molecular Weight:865.92
IUPAC Name: (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-acetoxy-6-((cyclopropanecarbonyl)oxy)-9-(((2R,3R)-3-(furan-2-yl)-2-hydroxy-3-((isobutoxycarbonyl)amino)propanoyl)oxy)-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-12-yl benzoate
InChIKey: VLNULAHOGSXBDZ-OAGWZNDDSA-N
SMILES: O=C([C@@H]([C@H](C1=CC=CO1)NC(OCC(C)C)=O)O)O[C@@H]2C(C)=C([C@H](C([C@]3(C)[C@H](C[C@@]([H])(OC4)[C@]4(OC(C)=O)[C@]3([C@@H]([C@@]5(C2)O)OC(C6=CC=CC=C6)=O)[H])O)=O)OC(C7CC7)=O)C5(C)C
Biological Activity: TL-310 is a novel, orally active Taxane analogue. TL-310 can be used in the research of solid tumors[1][2].
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TL-310 | TL-310 is a novel, orally active Taxane analogue. TL-310 can be used in the research of solid tumors. | |||||||||||||||||||||
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- [1]. Glasspool R M, et al. A phase I study of a novel taxane, TL310, orally administered every week in patients (pts) with advanced solid tumors. Journal of Clinical Oncology, 2007, 25(18_suppl): 2544-2544.
- [2]. Harris N, et al. Abstract# 5438: Metabolism of the oral taxane TL310 in vitro and in a Phase I study[J]. Cancer Research, 2009, 69(9_Supplement): 5438-5438.
Keywords
