35409-55-3
Chemical Structure
Pteroylhexaglutamate
Synonym(s): PteGlu6
- CAS No.: 35409-55-3
- Formula:C44H54N12O21
- Molecular Weight:1086.97
IUPAC Name: (3S,8S,13S,18S,23S,28S)-1-(4-(((2-amino-4-oxo-4,8-dihydropteridin-6-yl)methyl)amino)phenyl)-1,6,11,16,21,26-hexaoxo-2,7,12,17,22,27-hexaazatriacontane-3,8,13,18,23,28,30-heptacarboxylic acid
InChIKey: AIPNSTFJYXXLIP-QCOJBMJGSA-N
SMILES: O=C1C2=NC(CNC(C=C3)=CC=C3C(N[C@H](C(O)=O)CCC(N[C@H](C(O)=O)CCC(N[C@H](C(O)=O)CCC(N[C@H](C(O)=O)CCC(N[C@H](C(O)=O)CCC(N[C@H](C(O)=O)CCC(O)=O)=O)=O)=O)=O)=O)=O)=CNC2=NC(N)=N1
Biological Activity: Pteroylhexaglutamate (PteGlu6) inhibits the T2-phage-induced synthetase by 50% at 0.6 μM in the absence of Mg2+. Pteroylhexaglutamate is a substrate for pteroylpolyglutamate hydrolase, and can be used to monitor the activity of pteroylpolyglutamate hydrolase[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Pteroylhexaglutamate | Pteroylhexaglutamate (PteGlu6) inhibits the T2-phage-induced synthetase by 50% at 0.6 μM in the absence of Mg2+. Pteroylhexaglutamate is a substrate for pteroylpolyglutamate hydrolase, and can be used to monitor the activity of pteroylpolyglutamate hydrolase. | |||||||||||||||||||||
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- [1]. Maley GF, et al. Differential inhibition of host and viral thymidylate synthetases by folylpolyglutamates. J Biol Chem. 1979 Aug 25;254(16):7485-7. [Content Brief]
- [2]. Seyoum E, et al. Properties of food folates determined by stability and susceptibility to intestinal pteroylpolyglutamate hydrolase action. J Nutr. 1998 Nov;128(11):1956-60. [Content Brief]
Keywords
