360551-59-3
Chemical Structure
A-317920
- CAS No.: 360551-59-3
- Formula:C25H31N3O5
- Molecular Weight:453.53
IUPAC Name: (R)-N-(1-(4-(3-(4-(cyclopropanecarbonyl)phenoxy)propyl)piperazin-1-yl)-1-oxopropan-2-yl)furan-2-carboxamide
InChIKey: RTRADBQSZJIRMT-GOSISDBHSA-N
SMILES: O=C(N[C@@H](C(N1CCN(CC1)CCCOC2=CC=C(C=C2)C(C3CC3)=O)=O)C)C4=CC=CO4
Biological Activity: A-317920 is a selective and potent rat histamine H3 receptor (H3R) antagonist with pKi value of 9.2 and 7.0 for full-length rat and full-length human H3R, respectively. A-317920 exhibits over 130 fold selective affinity for the rat over the human H3R. A-317920 enhances cognition via H3R blockade[1].
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A-317920 | A-317920 is a selective and potent rat histamine H3 receptor (H3R) antagonist with pKi value of 9.2 and 7.0 for full-length rat and full-length human H3R, respectively. A-317920 exhibits over 130 fold selective affinity for the rat over the human H3R. A-317920 enhances cognition via H3R blockade. | |||||||||||||||||||||
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Keywords
