3650-73-5
3650-73-5
Chemical Structure
Homocarnosine
Synonym(s): L-Homocarnosine
- CAS No.: 3650-73-5
- Formula:C10H16N4O3
- Molecular Weight:240.26
IUPAC Name: (4-aminobutanoyl)-L-histidine
InChIKey: CCLQKVKJOGVQLU-QMMMGPOBSA-N
SMILES: O=C([C@@H](NC(CCCN)=O)CC1=CNC=N1)O
Biological Activity: Homocarnosine is a dipeptide of γ-aminobutyric acid (GABA) and histidine unique to brain. Homocarnosine is an inhibitory neuromodulator synthesized in the neuron from GABA and exhibiting anticonvulsant effects[1].Homocarnosine has antioxidant and anti-inflammatory actions, prevention of DNA damage, and inhibition of advanced glycation end-product formation[2].
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Homocarnosine | Homocarnosine is a dipeptide of γ-aminobutyric acid (GABA) and histidine unique to brain. Homocarnosine is an inhibitory neuromodulator synthesized in the neuron from GABA and exhibiting anticonvulsant effects.Homocarnosine has antioxidant and anti-inflammatory actions, prevention of DNA damage, and inhibition of advanced glycation end-product formation. | |||||||||||||||||||||
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References
- [1]. O A Petroff, et al. Vigabatrin increases human brain homocarnosine and improves seizure control. Ann Neurol. 1998 Dec;44(6):948-52. [Content Brief]
- [2]. Thanutchaporn Kumrungsee, et al. Dietary GABA induces endogenous synthesis of a novel imidazole peptide homocarnosine in mouse skeletal muscles. Amino Acids. 2020 May;52(5):743-753. [Content Brief]
