367909-40-8
Chemical Structure
MRS2279
- CAS No.: 367909-40-8
- Formula:C13H18ClN5O8P2
- Molecular Weight:469.71
IUPAC Name: ((1R,2S,4S,5S)-4-(2-chloro-6-(methylamino)-9H-purin-9-yl)-2-(phosphonooxy)bicyclo[3.1.0]hexan-1-yl)methyl dihydrogen phosphate
InChIKey: NDCFGYFBDZLTJB-SMWKGLLFSA-N
SMILES: O=[P](O)(O)OC[C@]1([C@H]2O[P](O)(O)=O)[C@]([C@](N3C4=NC(Cl)=NC(NC)=C4N=C3)([H])C2)([H])C1
Biological Activity: MRS2279 is a selective and high affinity P2Y1 receptor antagonist, with a Ki of 2.5 nM and an IC50 of 51.6 nM. MRS2279 competitively inhibits ADP-promoted platelet aggregation with an apparent affnity (pKB=8.05)[1][2][3].
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MRS2279 | MRS2279 is a selective and high affinity P2Y1 receptor antagonist, with a Ki of 2.5 nM and an IC50 of 51.6 nM. MRS2279 competitively inhibits ADP-promoted platelet aggregation with an apparent affnity (pKB=8.05). | |||||||||||||||||||||
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- [1]. Nandanan E, et al. Synthesis, biological activity, and molecular modeling of ribose-modified deoxyadenosine bisphosphate analogues as P2Y(1) receptor ligands. J Med Chem. 2000;43(5):829-842. [Content Brief]
- [2]. Boyer JL, et al, Ravi RG, Jacobson KA, Harden TK. 2-Chloro N(6)-methyl-(N)-methanocarba-2'-deoxyadenosine-3',5'-bisphosphate is a selective high affinity P2Y(1) receptor antagonist. Br J Pharmacol. 2002;135(8):2004-2010. [Content Brief]
- [3]. Wei W, et al. Mechanical ventilation induces lung and brain injury through ATP production, P2Y1 receptor activation and dopamine release. Bioengineered. 2022 Feb;13(2):2346-2359. [Content Brief]
Keywords
