375394-74-4
Chemical Structure
ADSS2-IN-1
- CAS No.: 375394-74-4
- Formula:C11H11N5
- Molecular Weight:213.24
IUPAC Name: 1-(1H-benzo[d]imidazol-2-yl)-3-methyl-1H-pyrazol-5-amine
InChIKey: NTNMPDQKBQRDHQ-UHFFFAOYSA-N
SMILES: CC1=NN(C(N)=C1)C2=NC3=C(N2)C=CC=C3
Biological Activity: ADSS2-IN-1 is a ADSS2 inhibitor. ADSS2-IN-1 inhibits de novo AMP biosynthesis by targeting ADSS2, downregulates AMPK activity and promotes mitophagy in drug-resistant cells. ADSS2-IN-1 alone induces mild apoptosis in acute myeloid leukemia cells, and acts synergistically with BH3 mimetics to enhance the apoptotic effect. ADSS2-IN-1 restores the sensitivity of drug-resistant acute myeloid leukemia cells and reduces disease burden in immunocompetent mouse models. ADSS2 antagonist-1 can be used for the research of acute myeloid leukemia[1].
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ADSS2-IN-1 | ADSS2-IN-1 is a ADSS2 inhibitor. ADSS2-IN-1 inhibits de novo AMP biosynthesis by targeting ADSS2, downregulates AMPK activity and promotes mitophagy in drug-resistant cells. ADSS2-IN-1 alone induces mild apoptosis in acute myeloid leukemia cells, and acts synergistically with BH3 mimetics to enhance the apoptotic effect. ADSS2-IN-1 restores the sensitivity of drug-resistant acute myeloid leukemia cells and reduces disease burden in immunocompetent mouse models. ADSS2 antagonist-1 can be used for the research of acute myeloid leukemia. | |||||||||||||||||||||
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