3776-37-2
Chemical Structure
Racemomycin B
Synonym(s): 229-B; Streptothricin D
- CAS No.: 3776-37-2
- Formula:C31H58N12O10
- Molecular Weight:758.87
IUPAC Name: (2R,3R,4S,5R,6R)-5-((S)-3-amino-6-((S)-3-amino-6-((S)-3,6-diaminohexanamido)hexanamido)hexanamido)-4-hydroxy-6-(((3aS,7R,7aS)-7-hydroxy-4-oxo-3a,4,5,6,7,7a-hexahydro-1H-imidazo[4,5-c]pyridin-2-yl)amino)-2-(hydroxymethyl)tetrahydro-2H-pyran-3-yl carbamate
InChIKey: WUJTXMVGXDQPNN-OTQKCRDJSA-N
SMILES: O=C(NC[C@H]1O)[C@]2([H])[C@]1([H])NC(N[C@H]3[C@@H]([C@@H]([C@@H](OC(N)=O)[C@@H](CO)O3)O)NC(C[C@@H](N)CCCNC(C[C@@H](N)CCCNC(C[C@@H](N)CCCN)=O)=O)=O)=N2
Biological Activity: Racemomycin B (229-B; Streptothricin D), the main component from Streptomyces lavendulae OP-2, is a streptothricin antibiotic containing three β-lysine groups. RM-B exhibits antimicrobial activity against plant pathogenic microorganisms and effectively inhibits the growth of Brassica rapa L. roots at 50 ppm. RM-B showed a minimum inhibitory concentration (MIC) of 0.4 μg/ml against Pseudomonas syringae pv. tabaci IFO-3508 and a MIC range of 0.1-2.0 μg/ml against six strains of Fusarium oxysporum, showing stronger antimicrobial activity than RM-A and RM-C. The biological activity of racemomycin compounds increases with the increase in the number of β-lysine groups.
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Racemomycin B | Racemomycin B (229-B; Streptothricin D), the main component from Streptomyces lavendulae OP-2, is a streptothricin antibiotic containing three β-lysine groups. RM-B exhibits antimicrobial activity against plant pathogenic microorganisms and effectively inhibits the growth of Brassica rapa L. roots at 50 ppm. RM-B showed a minimum inhibitory concentration (MIC) of 0.4 μg/ml against Pseudomonas syringae pv. tabaci IFO-3508 and a MIC range of 0.1-2.0 μg/ml against six strains of Fusarium oxysporum, showing stronger antimicrobial activity than RM-A and RM-C. The biological activity of racemomycin compounds increases with the increase in the number of β-lysine groups. | |||||||||||||||||||||
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Keywords
