388604-55-5
388604-55-5
Chemical Structure
CK-548
Synonym(s): CK-0993548
- CAS No.: 388604-55-5
- Formula:C15H11BrClNO2S
- Molecular Weight:384.68
IUPAC Name: 2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)thiazolidin-4-one
InChIKey: KEGQNJITMFBVAC-UHFFFAOYSA-N
SMILES: O=C1N(C(SC1)C2=CC=CC(Br)=C2)C3=CC(Cl)=CC=C3O
Biological Activity: CK-548 (CK-0993548) is a Arp2/3 complex inhibitor with the IC50 of 11 μM. CK-548 inhibits HIV-1 nuclear migration and infection[1][2].
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CK-548 | CK-548 (CK-0993548) is a Arp2/3 complex inhibitor with the IC50 of 11 μM. CK-548 inhibits HIV-1 nuclear migration and infection. | |||||||||||||||||||||
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References
- [1]. B. J. Nolen, et al. Characterization of two classes of small molecule inhibitors of Arp2/3 complex. Nature.
- [2]. Spear M, et al. HIV-1 triggers WAVE2 phosphorylation in primary CD4 T cells and macrophages, mediating Arp2/3-dependent nuclear migration. J Biol Chem. 2014;289(10):6949-6959. [Content Brief]
