393101-41-2
Chemical Structure
Milataxel
Synonym(s): MAC-321
- No. CAS: 393101-41-2
- Formula:C44H55NO16
- Molecular Weight:853.90
IUPAC Name: (2aR,4S,4aS,6R,9S,11S,12S,12bS)-12b-acetoxy-9-(((2R,3R)-3-((tert-butoxycarbonyl)amino)-3-(furan-2-yl)-2-hydroxypropanoyl)oxy)-6,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-4-(propionyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-12-yl benzoate
InChIKey: XIVMHSNIQAICTR-DMUFGCTNSA-N
SMILES: O=C(O[C@@H]1C(C)=C(C(C)2C)[C@@H](O)C([C@@]([C@@H](OC(CC)=O)C3)(C)C([C@@]4(OC(C)=O)[C@]3([H])OC4)[C@H](OC(C5=CC=CC=C5)=O)[C@]2(O)C1)=O)[C@H](O)[C@@H](NC(OC(C)(C)C)=O)C6=CC=CO6
Biological Activity: Milataxel (MAC-321) is an orally active taxane analog of Docetaxel (HY-B0011). Milataxel enhances the rate of tubulin polymerization. Milataxel can be used in the research of colorectal cancer and non-small cell lung cancer[1][2].
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Milataxel | Milataxel (MAC-321) is an orally active taxane analog of Docetaxel (HY-B0011). Milataxel enhances the rate of tubulin polymerization. Milataxel can be used in the research of colorectal cancer and non-small cell lung cancer. | |||||||||||||||||||||
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References
- [1]. Ramanathan RK, et al. A phase II study of milataxel: a novel taxane analogue in previously treated patients with advanced colorectal cancer. Cancer Chemother Pharmacol. 2008 Mar;61(3):453-8. [Content Brief]
- [2]. Mekhail T, et al. A phase II study of intravenous (IV) milataxel (M) for the treatment of non-small cell lung cancer (NSCLC) refractory to platinum-based therapy. Journal of Clinical Oncology, 2006, 24(18_suppl): 7098-7098.
