393856-87-6
Chemical Structure
KP 544
- CAS No.: 393856-87-6
- Formula:C18H19ClN4O
- Molecular Weight:342.82
IUPAC Name: (1r,4r)-4-((2-amino-5-((4-chlorophenyl)ethynyl)pyrimidin-4-yl)amino)cyclohexanol
InChIKey: XBVOXAWRUIZEMG-WKILWMFISA-N
SMILES: O[C@H]1CC[C@H](NC2=NC(N)=NC=C2C#CC3=CC=C(Cl)C=C3)CC1
Biological Activity: KP 544 is a potent neurotrophic protein enhancer that amplifies nerve growth factor (NGF)-induced neurite outgrowth of PC12 cells and SH-SY5Y neuroblastoma cells. KP544 also enhances choline acetyltransferase activity. KP 544 selectively interact in the differentiation pathway downstream of MAPK in a manner that amplifies nerve growth factor and cyclic AMP effects and is also neuroprotective[1].
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KP 544 | KP 544 is a potent neurotrophic protein enhancer that amplifies nerve growth factor (NGF)-induced neurite outgrowth of PC12 cells and SH-SY5Y neuroblastoma cells. KP544 also enhances choline acetyltransferase activity. KP 544 selectively interact in the differentiation pathway downstream of MAPK in a manner that amplifies nerve growth factor and cyclic AMP effects and is also neuroprotective. | |||||||||||||||||||||
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