396-01-0
396-01-0
Chemical Structure
Triamterene
- CAS. Nr.: 396-01-0
- Formula:C12H11N7
- Molecular Weight:253.26
IUPAC Name: 6-phenylpteridine-2,4,7-triamine
InChIKey: FNYLWPVRPXGIIP-UHFFFAOYSA-N
SMILES: NC1=NC(N)=C2N=C(C3=CC=CC=C3)C(N)=NC2=N1
Biological Activity: Triamterene blocks epithelial Na+ channel (ENaC) in a voltage-dependent manner, which used as a mild diuretic. Triamterene is an inhibitor of the TGR5 receptor[1][2].
| Art. -Nr. | Produktname | Reinheit | Beschreibung | Pricing | |||||||||||||||||||
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Triamterene | 99.90% | Triamterene blocks epithelial Na+ channel (ENaC) in a voltage-dependent manner, which used as a mild diuretic. Triamterene is an inhibitor of the TGR5 receptor. | ||||||||||||||||||||
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Triamterene (Standard) | 99.70% | Triamterene (Standard) is the analytical standard of Triamterene. This product is intended for research and analytical applications. Triamterene blocks epithelial Na+ channel (ENaC) in a voltage-dependent manner, which used as a mild diuretic. Triamterene as an inhibitor of the TGR5 receptor. | ||||||||||||||||||||
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Triamterene-d5 | 99.82% | Triamterene-d5 is deuterium labeled Triamterene (HY-B0575). Triamterene blocks epithelial Na+ channel (ENaC) in a voltage-dependent manner, which used as a mild diuretic. Triamterene is an inhibitor of the TGR5 receptor. | ||||||||||||||||||||
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TG100-115 (Standard) | ≥98% | TG100-115 (Standard) is the analytical standard of TG100-115 (HY-10111). This product is intended for research and analytical applications. TG100-115 is a selective PI3Kγ/PI3Kδ inhibitor with IC50s of 83 and 235 nM, respectively. | ||||||||||||||||||||
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RPH-2823 | RPH-2823, a basic triamterene derivative, induces a dose-dependent decrease in short-circuit current (SCC) and increase in transepithelial electrical resistance. | |||||||||||||||||||||
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2-Methyl-3-phenylquinoxaline | 98.70% | 2-Methyl-3-phenylquinoxaline (compound 38) is a potent platelet-derived growth factor receptor tyrosine kinase (PDGF-RTK) inhibitor with modest inhibitory activity against PDGFR kinase in intact cells (IC50 greater than 100 μM). | ||||||||||||||||||||
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NPD9948 | NPD9948 is an antitussive agent with antitussive activity in a guinea pig antitussive test. Its half antitussive dose (AtD50) is 14.5 mg/kg and 22.6 mg/kg when injected intraperitoneally and orally, respectively. | |||||||||||||||||||||
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Epiblastin A | 99.44% | Epiblastin A is an ATP-competitive casein kinase 1 (CK1) inhibitor that inhibits CK1α, CK1δ, and CK1ε. Epiblastin A inhibits the kinase activity of STK10, BRSK1, EEF2K, EGFR, MKNK2, and RIPK2. Epiblastin A inhibits Ki-67 expression, induces Oct4-GFP expression, and enhances the conversion of mouse epiblast stem cells to embryonic stem cells. Epiblastin A selectively reduces the cell viability of colorectal cancer cell lines HCT116, HT29, and DLD1. Epiblastin A can be used in colorectal cancer-related research. | ||||||||||||||||||||
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PhIP (Standard) | ≥98% | PhIP (Standard) is the analytical standard of PhIP. This product is intended for research and analytical applications. PhIP (2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine) is the most abundant of generation of heterocyclic amines (HCA), resulted in the cooking of meat. DNA damaging and mutagenic activities. PhIP also has oestrogenic activity that could contribute to its tissue specific carcinogenicity. | ||||||||||||||||||||
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TG 100713 | 99.21% | TG 100713 is an inhibitor of PI3K, with IC50s of 24, 50, 165, and 215 nM for PI3Kδ, γ, α and β isoforms respectively. | ||||||||||||||||||||
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PAQ | PAQ (Compound 4c) is a quinoxaline derivative. PAQ is an orally active neuroprotective agent, which targets dopamine (DA) neurons and activates reticulum endoplasmic ryanodine receptor (RyR) channels, without effects on glia cells. | |||||||||||||||||||||
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Acetyl-CoA Carboxylase-IN-1 | 99.18% | Acetyl-CoA Carboxylase-IN-1 is a potent acetyl-CoA carboxylase (ACC) inhibitor with an IC50 value of ＜5 nM. Acetyl-CoA Carboxylase-IN-1 has antibacterial activity. | ||||||||||||||||||||
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References
- [1]. Busch, A.E., et al., Blockade of epithelial Na+ channels by triamterenes - underlying mechanisms and molecular basis. Pflugers Arch, 1996. 432(5): p. 760-6. [Content Brief]
- [2]. Gilfrich, H.J., et al., Pharmacokinetics of triamterene after i.v. administration to man: determination of bioavailability. Eur J Clin Pharmacol, 1983. 25(2): p. 237-41. [Content Brief]
