396-01-0
396-01-0
Chemical Structure
Triamterene
- CAS No.: 396-01-0
- Formula:C12H11N7
- Molecular Weight:253.26
IUPAC Name: 6-phenylpteridine-2,4,7-triamine
InChIKey: FNYLWPVRPXGIIP-UHFFFAOYSA-N
SMILES: NC1=NC(N)=C2N=C(C3=CC=CC=C3)C(N)=NC2=N1
Biological Activity: Triamterene blocks epithelial Na+ channel (ENaC) in a voltage-dependent manner, which used as a mild diuretic. Triamterene is an inhibitor of the TGR5 receptor[1][2].
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Triamterene | 99.90% | Triamterene blocks epithelial Na+ channel (ENaC) in a voltage-dependent manner, which used as a mild diuretic. Triamterene is an inhibitor of the TGR5 receptor. | ||||||||||||||||||||
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Triamterene (Standard) | 99.70% | Triamterene (Standard) is the analytical standard of Triamterene. This product is intended for research and analytical applications. Triamterene blocks epithelial Na+ channel (ENaC) in a voltage-dependent manner, which used as a mild diuretic. Triamterene as an inhibitor of the TGR5 receptor. | ||||||||||||||||||||
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Triamterene-d5 | 99.82% | Triamterene-d5 is deuterium labeled Triamterene (HY-B0575). Triamterene blocks epithelial Na+ channel (ENaC) in a voltage-dependent manner, which used as a mild diuretic. Triamterene is an inhibitor of the TGR5 receptor. | ||||||||||||||||||||
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References
- [1]. Busch, A.E., et al., Blockade of epithelial Na+ channels by triamterenes - underlying mechanisms and molecular basis. Pflugers Arch, 1996. 432(5): p. 760-6. [Content Brief]
- [2]. Gilfrich, H.J., et al., Pharmacokinetics of triamterene after i.v. administration to man: determination of bioavailability. Eur J Clin Pharmacol, 1983. 25(2): p. 237-41. [Content Brief]
