1. Membrane Transporter/Ion Channel
  2. Sodium Channel
  3. Triamterene

Triamterene 

Cat. No.: HY-B0575 Purity: 99.17%
Handling Instructions

Triamterene blocks epithelial Na+ channel (ENaC) in a voltage-dependent manner, which used as a mild diuretic.

For research use only. We do not sell to patients.

Triamterene Chemical Structure

Triamterene Chemical Structure

CAS No. : 396-01-0

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10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
100 mg USD 60 In-stock
Estimated Time of Arrival: December 31
500 mg USD 108 In-stock
Estimated Time of Arrival: December 31
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Description

Triamterene blocks epithelial Na+ channel (ENaC) in a voltage-dependent manner, which used as a mild diuretic. Target: Sodium Channel Triamterene blocked rENaC in a voltage-dependent manner, and was 100-fold less potent than amiloride at pH 7.5. At -90 mV and -40 mV, the IC50 values were 5 microM and 10 microM, respectively. The blockage by triamterene, which is a weak base with a pKa of 6.2, was dependent on the extracellular pH. The IC50 was 1 microM at pH 6.5 and only 17 microM at pH 8.5 [1]. Triamterene (TA) is partly eliminated by a first-pass-effect. The main metabolite of TA is OH-TA-ester, which is pharmacologically active [2].

Clinical Trial
Molecular Weight

253.26

Formula

C₁₂H₁₁N₇

CAS No.

396-01-0

SMILES

NC1=NC(N)=C2N=C(C3=CC=CC=C3)C(N)=NC2=N1

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 10 mg/mL (39.49 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

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Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.9485 mL 19.7426 mL 39.4851 mL
5 mM 0.7897 mL 3.9485 mL 7.8970 mL
10 mM 0.3949 mL 1.9743 mL 3.9485 mL
*Please refer to the solubility information to select the appropriate solvent.
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Triamterene
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HY-B0575
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