39692-70-1
Chemical Structure
Aib-Aib
- CAS No.: 39692-70-1
- Formula:C8H16N2O3
- Molecular Weight:188.22
InChIKey: NRMLUZKYISNRAH-UHFFFAOYSA-N
SMILES: O=C(C(C)(C)NC(C(C)(C)N)=O)O
Biological Activity: Aib-Aib is a dipeptide compound formed by the condensation of two non-proteinogenic α-aminoisobutyric acid residues. Aib-Aib confers strong resistance to proteolytic degradation as a core component of natural peptaibols. Aib-Aib strongly induces and locks the peptide backbone into stable helical conformations through the massive steric hindrance of its dimethyl groups. Aib-Aib is widely used as a critical structural building block in long-acting peptide drug design, solid-phase synthesis optimization, and self-assembling bionanomaterial research[1][2][3][4].
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Aib-Aib | Aib-Aib is a dipeptide compound formed by the condensation of two non-proteinogenic α-aminoisobutyric acid residues. Aib-Aib confers strong resistance to proteolytic degradation as a core component of natural peptaibols. Aib-Aib strongly induces and locks the peptide backbone into stable helical conformations through the massive steric hindrance of its dimethyl groups. Aib-Aib is widely used as a critical structural building block in long-acting peptide drug design, solid-phase synthesis optimization, and self-assembling bionanomaterial research. | |||||||||||||||||||||
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References
- [1]. Rajagopal A, et al. Chain length effects on helix-hairpin distribution in short peptides with Aib-DAla and Aib-Aib segments. Biopolymers. 2011;96(6):744-56.
- [2]. Schweitzer-Stenner R, et al. Conformational manifold of alpha-aminoisobutyric acid (Aib) containing alanine-based tripeptides in aqueous solution explored by vibrational spectroscopy, electronic circular dichroism spectroscopy, and molecular dynamics simulations. Journal of the American Chemical Society. 2007 Oct 31;129(43):13095-109.
- [3]. Salnikov ES, et al. Structure and alignment of the membrane-associated peptaibols ampullosporin A and alamethicin by oriented 15N and 31P solid-state NMR spectroscopy. Biophys J. 2009 Jan;96(1):86-100.
- [4]. Lau J, et al. Discovery of the Once-Weekly Glucagon-Like Peptide-1 (GLP-1) Analogue Semaglutide. Journal of medicinal chemistry. 2015 Sep 24;58(18):7370-80. [Content Brief]
