4143-64-0
Chemical Structure
3',4'-Dihydroxyflavone
- CAS No.: 4143-64-0
- Formula:C15H10O4
- Molecular Weight:254.24
IUPAC Name: 2-(3,4-dihydroxyphenyl)-4H-chromen-4-one
InChIKey: SRNPMQHYWVKBAV-UHFFFAOYSA-N
SMILES: O=C1C=C(C2=CC=C(O)C(O)=C2)OC3=CC=CC=C13
Biological Activity: 3',4'-Dihydroxyflavone is an orally active antioxidant. 3',4'-Dihydroxyflavone inhibits the NF-κB, JAK1/STAT1, AP-1, IRF3, and MAPK/MEK/ERK pathways, while activating Nrf2 and reducing Keap1, thereby exerting anti-inflammatory and antioxidant effects. 3',4'-Dihydroxyflavone inhibits NO, PGE2, pro-inflammatory cytokines, and ROS production, upregulates GSH, and activates KATP channels, adenosine A3 receptors, and GABAA receptors. 3',4'-Dihydroxyflavone inhibits PPARγ expression and adipogenic differentiation, induces osteogenic differentiation; it also inhibits 5-lipoxygenase and xanthine oxidase, weakly inhibits PARP1, and scavenges DPPH and superoxide radicals. 3',4'-Dihydroxyflavone can be used for research on peripheral nerve injury, septic shock, obesity, influenza A virus infection, infertility, and diabetic complications[1][2][3][4][5][6][7][8][9][10].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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3',4'-Dihydroxyflavone | 98.62% | 3',4'-Dihydroxyflavone is an orally active antioxidant. 3',4'-Dihydroxyflavone inhibits the NF-κB, JAK1/STAT1, AP-1, IRF3, and MAPK/MEK/ERK pathways, while activating Nrf2 and reducing Keap1, thereby exerting anti-inflammatory and antioxidant effects. 3',4'-Dihydroxyflavone inhibits NO, PGE2, pro-inflammatory cytokines, and ROS production, upregulates GSH, and activates KATP channels, adenosine A3 receptors, and GABAA receptors. 3',4'-Dihydroxyflavone inhibits PPARγ expression and adipogenic differentiation, induces osteogenic differentiation; it also inhibits 5-lipoxygenase and xanthine oxidase, weakly inhibits PARP1, and scavenges DPPH and superoxide radicals. 3',4'-Dihydroxyflavone can be used for research on peripheral nerve injury, septic shock, obesity, influenza A virus infection, infertility, and diabetic complications. | ||||||||||||||||||||
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References
- [1]. Zhou Y, et al. Taxifolin increased semen quality of Duroc boars by improving gut microbes and blood metabolites. Frontiers in microbiology. 2022;13:1020628.
- [2]. Lee HH, et al. 3',4'-Dihydroxyflavone mitigates inflammatory responses by inhibiting LPS and TLR4/MD2 interaction. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 Jan;109:154553.
- [3]. Ramasamy K, et al. 3', 4'-dihydroxyflavone ameliorates paclitaxel model of peripheral neuropathy in mice by modulating KATP channel, adenosine (A3) and GABAA (α2 subunit) receptors. Bioinformation. 2023 Jun 30;19(6):754-763.
- [4]. Han J, et al. Regulation of Adipogenesis Through Differential Modulation of ROS and Kinase Signaling Pathways by 3,4'-Dihydroxyflavone Treatment. Journal of cellular biochemistry. 2017 May;118(5):1065-1077.
- [5]. Hossain MK, et al. Antiviral activity of 3,4'-dihydroxyflavone on influenza a virus. J Microbiol. 2014 Jun;52(6):521-6. [Content Brief]
- [6]. Ahamed TKS, et al. A ligand-based comparative molecular field analysis (CoMFA) and homology model based molecular docking studies on 3', 4'-dihydroxyflavones as rat 5-lipoxygenase inhibitors: Design of new inhibitors. Computational biology and chemistry. 2017 Dec;71:188-200.
- [7]. Benson S. Identification and characterisation of novel, natural product inhibitors of the poly (ADP‑ribose) polymerase (PARP) enzyme for anti‑cancer and other therapeutic applications [doctoral thesis]. Liverpool John Moores University; 2023.
- [8]. Chan K, et al. Predictive QSAR model confirms flavonoids in Chinese medicine can activate voltage-gated calcium (CaV) channel in osteogenesis. Chinese medicine. 2020;15:31.
- [9]. Pirnia A, et al. Effects of 3,4‑Dihydroxyflavone on Cryopreserved Testicular Tissue of Neonatal Mouse. Herbal Medicines Journal. Winter 2017;2(1):18‑25.
- [10]. Matsuda H, et al. Structural requirements of flavonoids for inhibition of protein glycation and radical scavenging activities. Bioorganic & medicinal chemistry. 2003 Dec 01;11(24):5317-23.
