422281-45-6
Chemical Structure
SW083688
- CAS No.: 422281-45-6
- Formula:C23H25N3O5S
- Molecular Weight:455.53
IUPAC Name: N-((2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)-3-(3-ethoxypropyl)-4-oxo-2-thioxo-1,2,3,4-tetrahydroquinazoline-7-carboxamide
InChIKey: CMHKKTGCFWZUEZ-UHFFFAOYSA-N
SMILES: O=C(C1=CC(NC(N2CCCOCC)=S)=C(C=C1)C2=O)NCC3OC4=CC=CC=C4OC3
Biological Activity: SW083688 is a selective TAOK2 inhibitor with an IC50 of 1.3 μM. SW083688 increases the abundance of p62 protein, inhibits autophagosome maturation, and blocks Autophagic flux. SW083688 is applicable for the research of non-small cell lung cancer and pancreatic cancer[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
SW083688 | 99.78% | SW083688 is a selective TAOK2 inhibitor with an IC50 of 1.3 μM. SW083688 increases the abundance of p62 protein, inhibits autophagosome maturation, and blocks Autophagic flux. SW083688 is applicable for the research of non-small cell lung cancer and pancreatic cancer. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
- [1]. Ye J, et al. Research Advances in the Molecular Functions and Relevant Diseases of TAOKs, Novel STE20 Kinase Family Members. Curr Pharm Des. 2020;26(26):3122-3133. [Content Brief]
- [2]. Piala AT, et al. Discovery of novel TAOK2 inhibitor scaffolds from high-throughput screening. Bioorg Med Chem Lett. 2016;26(16):3923-3927. [Content Brief]
Keywords
