438204-56-9
Chemical Structure
MKI-2
- CAS No.: 438204-56-9
- Formula:C22H19N7
- Molecular Weight:381.43
InChIKey: NVMCVWOODOWOLT-UHFFFAOYSA-N
SMILES: N#CCC1=CC=C(NC2=NC(NC3=NNC(C4CC4)=C3)=C5C=CC=CC5=N2)C=C1
Biological Activity: MKI-2 is a selective MASTL inhibitor with an IC50 of 37.44 nM. MKI-2 induces mitotic catastrophe resulting from the modulation of the MASTL-PP2A axis in breast cancer cells. MKI-2 reduces phospho-ENSA, total, phospho-c-Myc levels. MKI-2 inhibts cancer cells proliferation, migration and induces DNA damage. MKI-2 inhibits germinal vesicle breakdown in mouse oocytes. MKI-2 can be used for the research of cancer, such as breast cancer[1].
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MKI-2 | MKI-2 is a selective MASTL inhibitor with an IC50 of 37.44 nM. MKI-2 induces mitotic catastrophe resulting from the modulation of the MASTL-PP2A axis in breast cancer cells. MKI-2 reduces phospho-ENSA, total, phospho-c-Myc levels. MKI-2 inhibts cancer cells proliferation, migration and induces DNA damage. MKI-2 inhibits germinal vesicle breakdown in mouse oocytes. MKI-2 can be used for the research of cancer, such as breast cancer. | |||||||||||||||||||||
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Keywords
