439144-75-9
439144-75-9
Chemical Structure
JMX0312
- CAS. Nr.: 439144-75-9
- Formula:C14H8ClF4NO2
- Molecular Weight:333.67
IUPAC Name: 5-chloro-N-(3-fluoro-5-(trifluoromethyl)phenyl)-2-hydroxybenzamide
InChIKey: ZNPREQSETWFCPD-UHFFFAOYSA-N
SMILES: O=C(C1=CC(Cl)=CC=C1O)NC2=CC(F)=CC(C(F)(F)F)=C2
Biological Activity: JMX0312 is a small-molecule salicylamide derivative with submicromolar anti-human adenovirus activity, with an IC50 of 0.18 μM. JMX0312 reduces viral loads in the liver and blood and decreases mortality in immunosuppressed hamsters infected with human adenovirus, and it can be used for research on human adenovirus infection[1][2].
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JMX0312 | JMX0312 is a small-molecule salicylamide derivative with submicromolar anti-human adenovirus activity, with an IC50 of 0.18 μM. JMX0312 reduces viral loads in the liver and blood and decreases mortality in immunosuppressed hamsters infected with human adenovirus, and it can be used for research on human adenovirus infection. | |||||||||||||||||||||
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References
- [1]. Xu J, et al. Structure-Activity Relationship Studies on Diversified Salicylamide Derivatives as Potent Inhibitors of Human Adenovirus Infection. Journal of medicinal chemistry. 2020 Mar 26;63(6):3142-3160. [Content Brief]
- [2]. Carretero-Ledesma M, et al. Salicylamide derivative JMX0312 protects immunosuppressed Syrian hamsters against adenovirus lethal challenge. Antiviral research. 2025 Jun;238:106155.
