468-76-8
Chemical Structure
Cassaine
Synonym(s): Nervocidine
- CAS No.: 468-76-8
- Formula:C24H39NO4
- Molecular Weight:405.58
IUPAC Name: 2-(dimethylamino)ethyl 2-((1R,4aS,4bR,7S,8aR,10aS,E)-7-hydroxy-1,4b,8,8-tetramethyl-10-oxododecahydrophenanthren-2(1H)-ylidene)acetate
InChIKey: GMHWATCMBXIANN-IOJUAHGHSA-N
SMILES: C[C@@]12[C@](C(C)(C)[C@@H](O)CC1)(CC(=O)[C@@]3([C@@]2(CC/C(=C\C(OCCN(C)C)=O)/[C@@H]3C)[H])[H])[H]
Biological Activity: Cassaine (Nervocidine) is a Na+/K+-ATPase inhibitor. Cassaine stabilizes phosphorylated intermediates, slows spontaneous dephosphorylation and blocks potassium-stimulated dephosphorylation. Cassaine exhibits non-competitive inhibition with respect to K+, shows inhibition enhanced by Pi and antagonized by Na+. Cassaine induces positive inotropic effects in perfused hearts with faster inotropy offset. Cassaine can be used for research on cardiac arrhythmias[1][2].
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Cassaine | Cassaine (Nervocidine) is a Na+/K+-ATPase inhibitor. Cassaine stabilizes phosphorylated intermediates, slows spontaneous dephosphorylation and blocks potassium-stimulated dephosphorylation. Cassaine exhibits non-competitive inhibition with respect to K+, shows inhibition enhanced by Pi and antagonized by Na+. Cassaine induces positive inotropic effects in perfused hearts with faster inotropy offset. Cassaine can be used for research on cardiac arrhythmias. | |||||||||||||||||||||
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