475595-06-3
Chemical Structure
Antiviral agent 85
- CAS No.: 475595-06-3
- Formula:C20H24N2O
- Molecular Weight:308.42
InChIKey: YBAFDECFZYBOSU-FYJGNVAPSA-N
SMILES: O=C(N/N=C/C1=CC=C(C(C)(C)C)C=C1)C2=CC=C(C)C=C2C
Biological Activity: Antiviral agent 85 is a broad-spectrum arenavirus entry inhibitor with an EC90 of 0.13 µM against Junín virus (JUNV). Antiviral agent 85 blocks the entry of various arenaviruses through both hTfR1-dependent and hTfR1-independent pathways, acting on the early and early post-entry stages of infection. Antiviral agent 85 exhibits antiviral activity against a variety of arenaviruses, is well tolerated in hTfR1-expressing JUNV-infected mouse models, but fails to provide protective effects. Antiviral agent 85 can be used in studies related to arenavirus hemorrhagic fevers[1].
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Antiviral agent 85 | Antiviral agent 85 is a broad-spectrum arenavirus entry inhibitor with an EC90 of 0.13 µM against Junín virus (JUNV). Antiviral agent 85 blocks the entry of various arenaviruses through both hTfR1-dependent and hTfR1-independent pathways, acting on the early and early post-entry stages of infection. Antiviral agent 85 exhibits antiviral activity against a variety of arenaviruses, is well tolerated in hTfR1-expressing JUNV-infected mouse models, but fails to provide protective effects. Antiviral agent 85 can be used in studies related to arenavirus hemorrhagic fevers. | |||||||||||||||||||||
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Keywords
