478-29-5
478-29-5
Chemical Structure
Morindone
- CAS No.: 478-29-5
- Formula:C15H10O5
- Molecular Weight:270.24
InChIKey: BATFHSIVMJJJAF-UHFFFAOYSA-N
SMILES: O=C1C2=CC=C(C)C(O)=C2C(C3=CC=C(C(O)=C13)O)=O
Biological Activity: Morindone is an anthraquinone found in Morinda citrifolia L. Morindone can inhibit cancer cells proliferation, induce apoptosis and cause G1 phase arrest. Morindone can inhibit activities of DNA polymerase and downregulate mutated TP53 and KRAS gene expression. Morindone can be used for the research of cancer, such as colon cancer[1][2].
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Morindone | Morindone is an anthraquinone found in Morinda citrifolia L. Morindone can inhibit cancer cells proliferation, induce apoptosis and cause G1 phase arrest. Morindone can inhibit activities of DNA polymerase and downregulate mutated TP53 and KRAS gene expression. Morindone can be used for the research of cancer, such as colon cancer. | |||||||||||||||||||||
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References
- [1]. Chee CW, et al. Morindone as a potential therapeutic compound targeting TP53 and KRAS mutations in colorectal cancer cells. Chem Biol Interact. 2024 Apr 1;392:110928. [Content Brief]
- [2]. Cheok Wui Chee, et al. Morindone as a potential therapeutic compound targeting TP53 and KRAS mutations in colorectal cancer cells, Chemico-Biological Interactions, Volume 392, 2024, 110928, ISSN 0009-2797.
Keywords
