478908-51-9
Chemical Structure
GGTI-2166
- CAS No.: 478908-51-9
- Formula:C25H30N4O3
- Molecular Weight:434.54
IUPAC Name: methyl (5-(((1H-imidazol-5-yl)methyl)amino)-2'-methyl-[1,1'-biphenyl]-2-carbonyl)-L-leucinate
InChIKey: JXEKQPYTJAWNTO-QHCPKHFHSA-N
SMILES: C(N[C@H](C(OC)=O)CC(C)C)(=O)C1=C(C=C(NCC2=CN=CN2)C=C1)C3=C(C)C=CC=C3
Biological Activity: GGTI-2166 is a geranylgeranyltransferase I (GGTase I) inhibitor. GGTI-2166 blocks geranylgeranylation modification of target proteins. GGTI-2166 inhibits RANKL- or TNF-α-induced pre-osteoclast formation and TRAP activity. GGTI-2166 is applicable to research on osteoclast differentiation[1].
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GGTI-2166 | GGTI-2166 is a geranylgeranyltransferase I (GGTase I) inhibitor. GGTI-2166 blocks geranylgeranylation modification of target proteins. GGTI-2166 inhibits RANKL- or TNF-α-induced pre-osteoclast formation and TRAP activity. GGTI-2166 is applicable to research on osteoclast differentiation. | |||||||||||||||||||||
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- [1]. Woo JT, et al. Inhibitory effects of mevastatin and a geranylgeranyl transferase I inhibitor (GGTI-2166) on mononuclear osteoclast formation induced by receptor activator of NF kappa B ligand (RANKL) or tumor necrosis factor-alpha (TNF-alpha). Biochem Pharmacol. 2005;69(1):87-95. [Content Brief]
Keywords
