480446-44-4
Chemical Structure
UFP-512
- CAS No.: 480446-44-4
- Formula:C31H33N5O5
- Molecular Weight:555.62
IUPAC Name: (S)-3-((S)-2-((S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamido)-3-(1H-benzo[d]imidazol-2-yl)propanoic acid
InChIKey: USVQTDLSVBRMCR-YGPDHOBYSA-N
SMILES: CC(C=C(C=C1C)O)=C1C[C@H](N)C(N2[C@@H](CC3=CC=CC=C3C2)C(N[C@H](C4=NC5=CC=CC=C5N4)CC(O)=O)=O)=O
Biological Activity: UFP-512 is a selective and potent σ-opioid receptor (DOP receptor) peptidic agonist with antidepressant- and anxiolytic-like effects. UFP-512 exhibits as a potent agonist on adenylyl cyclase inhibition and Erk1/2 activation. UFP-512 induces phosphorylation of DOP receptors on Ser363 with a low desensitization of the cAMP pathway. UFP-512 is promising for research of mood disorders[1].
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UFP-512 | UFP-512 is a selective and potent σ-opioid receptor (DOP receptor) peptidic agonist with antidepressant- and anxiolytic-like effects. UFP-512 exhibits as a potent agonist on adenylyl cyclase inhibition and Erk1/2 activation. UFP-512 induces phosphorylation of DOP receptors on Ser363 with a low desensitization of the cAMP pathway. UFP-512 is promising for research of mood disorders. | |||||||||||||||||||||
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Keywords
