484-73-1
Chemical Structure
Pyrocoll
- CAS No.: 484-73-1
- Formula:C10H6N2O2
- Molecular Weight:186.17
IUPAC Name: 5H,10H-dipyrrolo[1,2-a:1',2'-d]pyrazine-5,10-dione
InChIKey: USCZWOZHDDOBHQ-UHFFFAOYSA-N
SMILES: O=C(C1=CC=CN1C2=O)N3C2=CC=C3
Biological Activity: Pyrocoll is a bacterial metabolite originally isolated from Streptomyces. It inhibits the growth of A. aurescens, A. globiformis, A. oxydans, A. pascens, and R. erythropolis bacteria (MICs=10, 1, 10, 3, and 10 μg/mL, respectively) and HMO2, HepG2, and MCF-7 cancer cells (GI50s=0.28, 0.42, and 2.2 μg/mL, respectively) in vitro. Pyrocoll is also active against P. falciparum and T. rhodesiense (IC50s=1.19 and 1.97 μg/mL, respectively).
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Pyrocoll | Pyrocoll is a bacterial metabolite originally isolated from Streptomyces. It inhibits the growth of A. aurescens, A. globiformis, A. oxydans, A. pascens, and R. erythropolis bacteria (MICs=10, 1, 10, 3, and 10 μg/mL, respectively) and HMO2, HepG2, and MCF-7 cancer cells (GI50s=0.28, 0.42, and 2.2 μg/mL, respectively) in vitro. Pyrocoll is also active against P. falciparum and T. rhodesiense (IC50s=1.19 and 1.97 μg/mL, respectively). | |||||||||||||||||||||
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Keywords
