499773-67-0
Chemical Structure
ErbB-2-binding peptide-2
Synonym(s): KCCYSL
- CAS No.: 499773-67-0
- Formula:C30H49N7O9S2
- Molecular Weight:715.88
InChIKey: WPZPUDYAMRTIGH-BTNSXGMBSA-N
SMILES: O=C(N[C@@H](CS)C(N[C@@H](CS)C(N[C@@H](CC1=CC=C(C=C1)O)C(N[C@@H](CO)C(N[C@@H](CC(C)C)C(O)=O)=O)=O)=O)=O)[C@H](CCCCN)N
Biological Activity: ErbB-2-binding peptide-2 (KCCYSL) is a peptide targeting ErbB-2/HER2, which specifically binds to the extracellular domain of HER2 and accumulates in HER2-expressing cancer cells. When radiolabeled, ErbB-2-binding peptide-2 serves as a SPECT/CT and PET imaging agent, enabling the visualization of HER2-expressing tumor xenografts. ErbB-2-binding peptide-2 is applicable to research related to ovarian cancer and breast cancer[1][2].
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ErbB-2-binding peptide-2 | ErbB-2-binding peptide-2 (KCCYSL) is a peptide targeting ErbB-2/HER2, which specifically binds to the extracellular domain of HER2 and accumulates in HER2-expressing cancer cells. When radiolabeled, ErbB-2-binding peptide-2 serves as a SPECT/CT and PET imaging agent, enabling the visualization of HER2-expressing tumor xenografts. ErbB-2-binding peptide-2 is applicable to research related to ovarian cancer and breast cancer. | |||||||||||||||||||||
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References
- [1]. Deutscher SL, et al. In-labeled KCCYSL peptide as an imaging probe for ErbB-2-expressing ovarian carcinomas. Journal of labelled compounds & radiopharmaceuticals. 2009 Dec 01;52(14):583-590. [Content Brief]
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[2]. Leung, K. (2012). 64Cu-Bis (carboxymethyl)-1, 4, 8, 11-tetraazabicyclo [6.6. 2] hexadecane-(Gly-Ser-Gly)-Lys-Cys-Cys-Tyr-Ser-Leu. Molecular Imaging and Contrast Agent Database (MICAD)[Internet].
