500287-94-5
500287-94-5
Chemical Structure
(Z)-Rilpivirine
Synonym(s): (Z)-R278474; (Z)-TMC278; (Z)-DB08864
- CAS No.: 500287-94-5
- Formula:C22H18N6
- Molecular Weight:366.42
InChIKey: YIBOMRUWOWDFLG-ARJAWSKDSA-N
SMILES: CC(C=C(C=C1C)/C=C\C#N)=C1NC2=NC(NC3=CC=C(C=C3)C#N)=NC=C2
Biological Activity: (Z)-Rilpivirine ((Z)-R278474) is the (Z)-isomer of Rilpivirine (HY-10574). Rilpivirine is an effective and selective diarylpyrimidine (DAPY) non-nucleoside reverse transcriptase inhibitor (NNRTI). It exhibits potent antiviral activity against both wild-type HIV (EC50 = 0.4 nM) and mutant strains (EC50 = 0.1-2.0 nM)[1].
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(Z)-Rilpivirine | (Z)-Rilpivirine ((Z)-R278474) is the (Z)-isomer of Rilpivirine (HY-10574). Rilpivirine is an effective and selective diarylpyrimidine (DAPY) non-nucleoside reverse transcriptase inhibitor (NNRTI). It exhibits potent antiviral activity against both wild-type HIV (EC50 = 0.4 nM) and mutant strains (EC50 = 0.1-2.0 nM). | |||||||||||||||||||||
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References
Keywords
