501926-82-5
Chemical Structure
MN-25
- CAS No.: 501926-82-5
- Formula:C26H37N3O3
- Molecular Weight:439.59
IUPAC Name: 7-methoxy-1-(2-morpholinoethyl)-N-((1S,2S,4R)-1,3,3-trimethylbicyclo[2.2.1]heptan-2-yl)-1H-indole-3-carboxamide
InChIKey: VQGDMQICNRCQEH-UFKXBGGNSA-N
SMILES: C[C@]1(C[C@](CC1)([H])C2(C)C)[C@@H]2NC(C3=CN(C4=C(OC)C=CC=C43)CCN5CCOCC5)=O
Biological Activity: MN-25 (compound 4a) is an orally active indolpyridone that serves as a novel cannabinoid ligand. MN-25 has Ki of 245 nM and 11 nM for CB1 and CB2. MN-25 has CB2 agonist activity and inhibits TNF-R release in human peripheral blood mononuclear cells in vitro with an IC50 of 33 μM. MN-25 shows efficacy in a mouse acute inflammation model at oral doses up to 50 mg/kg>[1].
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MN-25 | MN-25 (compound 4a) is an orally active indolpyridone that serves as a novel cannabinoid ligand. MN-25 has Ki of 245 nM and 11 nM for CB1 and CB2. MN-25 has CB2 agonist activity and inhibits TNF-R release in human peripheral blood mononuclear cells in vitro with an IC50 of 33 μM. MN-25 shows efficacy in a mouse acute inflammation model at oral doses up to 50 mg/kg>. | |||||||||||||||||||||
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