5090-88-0
Chemical Structure
Mansonone F
- CAS No.: 5090-88-0
- Formula:C15H12O3
- Molecular Weight:240.25
IUPAC Name: 3,6,9-trimethylbenzo[de]chromene-7,8-dione
InChIKey: WSRLWSPFIOAYST-UHFFFAOYSA-N
SMILES: O=C1C2=C3C(C(C)=COC3=C(C1=O)C)=CC=C2C
Biological Activity: Mansonone F acts as an estrogen receptor antagonist and an antimicrobial agent. Mansonone F effectively inhibits 17β-estradiol-induced β-galactosidase activity. Derivatives of Mansonone F also exhibit antioxidant and anti-Staphylococcus aureus biological activities. Mansonone F can be used in studies related to Staphylococcus aureus infections and methicillin-resistant Staphylococcus aureus (MRSA) infections[1][2].
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Mansonone F | Mansonone F acts as an estrogen receptor antagonist and an antimicrobial agent. Mansonone F effectively inhibits 17β-estradiol-induced β-galactosidase activity. Derivatives of Mansonone F also exhibit antioxidant and anti-Staphylococcus aureus biological activities. Mansonone F can be used in studies related to Staphylococcus aureus infections and methicillin-resistant Staphylococcus aureus (MRSA) infections. | |||||||||||||||||||||
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References
- [1]. El-Halawany AM, et al. Anti-estrogenic activity of mansorins and mansonones from the heartwood of Mansonia gagei DRUMM. Chemical & pharmaceutical bulletin. 2007 Sep;55(9):1332-7. [Content Brief]
- [2]. Chen X, et al. IG1, a mansonone F analog, exhibits antibacterial activity against Staphylococcus aureus by potentially impairing cell wall synthesis and DNA replication[J]. Life, 2022, 12(11): 1902.
