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Cat. No.: HY-119528

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Mansonone F

Mansonone F acts as an estrogen receptor antagonist and an antimicrobial agent. Mansonone F effectively inhibits 17β-estradiol-induced β-galactosidase activity. Derivatives of Mansonone F also exhibit antioxidant and anti-Staphylococcus aureus biological activities. Mansonone F can be used in studies related to Staphylococcus aureus infections and methicillin-resistant Staphylococcus aureus (MRSA) infections.

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CAS No.: 5090-88-0
화학식: C₁₅H₁₂O₃
분자량:240.25

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (276 KB)

Mansonone F Chemical Structure

CAS No.: 5090-88-0

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

ERα

ERβ

All Estrogen Receptor/ERR Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
CNE-2	IC₅₀	27.34 μM Compound: Msn F, MF	Antitumor against human CNE2 cells assessed as cell survival after 48 hrs by MTT assay Antitumor against human CNE2 cells assessed as cell survival after 48 hrs by MTT assay	[PMID: 21600681]

In Vitro

Mansonone F (10^-6-10^-4 M; 4 h) exhibits concentration-dependent anti-estrogenic activity in ERα-expressing yeast cells, reducing 17β-estradiol-induced β-galactosidase activity to 40.4% of control at 10^-4 M and 70.2% of control at 10^-5 M^[1].
Mansonone F (10^-6-10^-4 M; 4 h) exhibits concentration-dependent anti-estrogenic activity in ERβ-expressing yeast cells, reducing 17β-estradiol-induced β-galactosidase activity to 35.6% of control at 10^-4 M and 61.8% of control at 10^-5 M, with greater potency against ERβ than ERα^[1].
Mansonone F (10^-5-5×10^-3 M) exhibits potent concentration-dependent binding affinity to ERα, reducing labeled estrogen binding to 45.1% of control at 5×10^-3 M^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 5090-88-0
분자량 240.25
화학식 C₁₅H₁₂O₃
SMILES

O=C1C2=C3C(C(C)=COC3=C(C1=O)C)=CC=C2C
Structure Classification
- Terpenoids
- Sesquiterpenes
- Quinones
- Naphthalene Quinones
Initial Source
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. El-Halawany AM, et al. Anti-estrogenic activity of mansorins and mansonones from the heartwood of Mansonia gagei DRUMM. Chemical & pharmaceutical bulletin. 2007 Sep;55(9):1332-7. [Content Brief]

[2]. Chen X, et al. IG1, a mansonone F analog, exhibits antibacterial activity against Staphylococcus aureus by potentially impairing cell wall synthesis and DNA replication[J]. Life, 2022, 12(11): 1902.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

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Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
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상품명:
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Mansonone F

All Estrogen Receptor/ERR Isoforms