Mansonone F
Mansonone F acts as an estrogen receptor antagonist and an antimicrobial agent. Mansonone F effectively inhibits 17β-estradiol-induced β-galactosidase activity. Derivatives of Mansonone F also exhibit antioxidant and anti-Staphylococcus aureus biological activities. Mansonone F can be used in studies related to Staphylococcus aureus infections and methicillin-resistant Staphylococcus aureus (MRSA) infections.
For research use only. We do not sell to patients.
- CAS No.: 5090-88-0
- Formula: C15H12O3
- Molecular Weight:240.25
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
ERα |
ERβ |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| CNE-2 | IC50 |
27.34 μM
Compound: Msn F, MF
|
Antitumor against human CNE2 cells assessed as cell survival after 48 hrs by MTT assay
Antitumor against human CNE2 cells assessed as cell survival after 48 hrs by MTT assay
|
[PMID: 21600681] |
Mansonone F (10-6-10-4 M; 4 h) exhibits concentration-dependent anti-estrogenic activity in ERα-expressing yeast cells, reducing 17β-estradiol-induced β-galactosidase activity to 40.4% of control at 10-4 M and 70.2% of control at 10-5 M[1].
Mansonone F (10-6-10-4 M; 4 h) exhibits concentration-dependent anti-estrogenic activity in ERβ-expressing yeast cells, reducing 17β-estradiol-induced β-galactosidase activity to 35.6% of control at 10-4 M and 61.8% of control at 10-5 M, with greater potency against ERβ than ERα[1].
Mansonone F (10-5-5×10-3 M) exhibits potent concentration-dependent binding affinity to ERα, reducing labeled estrogen binding to 45.1% of control at 5×10-3 M[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 5090-88-0
-
Molecular Weight 240.25
-
Formula C15H12O3
-
SMILES
O=C1C2=C3C(C(C)=COC3=C(C1=O)C)=CC=C2C
-
Structure Classification
-
Initial Source
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Mansonone F Related Classifications
HY-119528 Related Classifications
Powered by Bioz