50995-53-4
Chemical Structure
O-Desmethyl-N-deschlorobenzoyl Indomethacin
- CAS No.: 50995-53-4
- Formula:
- Molecular Weight:205.21
IUPAC Name: 2-(5-hydroxy-2-methyl-1H-indol-3-yl)acetic acid
InChIKey: FDADMESSMPJUJC-UHFFFAOYSA-N
SMILES: CC1=C(CC(=O)O)C2=C(C=CC(=C2)O)N1
Biological Activity: O-Desmethyl-N-deschlorobenzoyl indomethacin is a metabolite of the non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor indomethacin (HY-14397). It is formed from indomethacin in isolated rabbit hepatocytes. O-Desmethyl-N-deschlorobenzoyl indomethacin (600 μM) decreases the viability of HL-60 leukemia cells when cultured with glucose oxidase. It has also been used in the synthesis of prostaglandin D2 (HY-101988) receptor antagonists.
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O-Desmethyl-N-deschlorobenzoyl Indomethacin | O-Desmethyl-N-deschlorobenzoyl indomethacin is a metabolite of the non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor indomethacin (HY-14397). It is formed from indomethacin in isolated rabbit hepatocytes. O-Desmethyl-N-deschlorobenzoyl indomethacin (600 μM) decreases the viability of HL-60 leukemia cells when cultured with glucose oxidase. It has also been used in the synthesis of prostaglandin D2 (HY-101988) receptor antagonists. | |||||||||||||||||||||
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