524722-52-9
524722-52-9
Chemical Structure
Vandetanib hydrochloride
Synonym(s): ZD6474 hydrochloride
- CAS. Nr.: 524722-52-9
- Formula:C22H25BrClFN4O2
- Molecular Weight:511.81
IUPAC Name: N-(4-bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine hydrochloride
InChIKey: KVBQCJXMSFJOFP-UHFFFAOYSA-N
SMILES: FC1=CC(Br)=CC=C1NC2=NC=NC3=CC(OCC4CCN(CC4)C)=C(C=C23)OC.[H]Cl
Biological Activity: Vandetanib hydrochloride (D6474 hydrochloride) is a potent, orally active inhibitor of VEGFR2/KDR tyrosine kinase activity (IC50=40 nM). Vandetanib hydrochloride also has activity versus the tyrosine kinase activity of VEGFR3/FLT4 (IC50=110 nM) and EGFR/HER1 (IC50=500 nM)[1].
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Vandetanib hydrochloride | Vandetanib hydrochloride (D6474 hydrochloride) is a potent, orally active inhibitor of VEGFR2/KDR tyrosine kinase activity (IC50=40 nM). Vandetanib hydrochloride also has activity versus the tyrosine kinase activity of VEGFR3/FLT4 (IC50=110 nM) and EGFR/HER1 (IC50=500 nM). | |||||||||||||||||||||
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