52645-97-3
52645-97-3
Chemical Structure
Siegeskaurolic acid
- CAS No.: 52645-97-3
- Formula:C20H32O3
- Molecular Weight:320.47
IUPAC Name: (4R,4aS,6aS,8R,9R,11aR,11bS)-8-(hydroxymethyl)-4,11b-dimethyltetradecahydro-6a,9-methanocyclohepta[a]naphthalene-4-carboxylic acid
InChIKey: HHAMKMUMKLXDFQ-IHAQYFQTSA-N
SMILES: C[C@]1(CCC2)[C@@]3([H])[C@@](C[C@H]4CO)(CC[C@]1([H])[C@]2(C)C(O)=O)C[C@H]4CC3
Biological Activity: Siegeskaurolic acid is an orally active anti-inflammatory agent. Siegeskaurolic acid inhibits the productions of nitric oxide (NO), prostaglandin E(2) (PGE(2)), tumor necrosis factor-alpha (TNF-alpha) and the activationon of nuclear factor-kappaB [1].
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Siegeskaurolic acid | Siegeskaurolic acid is an orally active anti-inflammatory agent. Siegeskaurolic acid inhibits the productions of nitric oxide (NO), prostaglandin E(2) (PGE(2)), tumor necrosis factor-alpha (TNF-alpha) and the activationon of nuclear factor-kappaB . | |||||||||||||||||||||
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References
- [1]. Park HJ, et al. Anti-inflammatory activities of ent-16alphaH,17-hydroxy-kauran-19-oic acid isolated from the roots of Siegesbeckia pubescens are due to the inhibition of iNOS and COX-2 expression in RAW 264.7 macrophages via NF-kappaB inactivation. Eur J Pharmacol. 2007;558(1-3):185-193. [Content Brief]
