531-73-7
531-73-7
Chemical Structure
3,6-Diaminoacridine dihydrochloride
- CAS No.: 531-73-7
- Formula:C13H13Cl2N3
- Molecular Weight:282.17
IUPAC Name: acridine-3,6-diamine dihydrochloride
InChIKey: YHIHFKAEJAVELI-UHFFFAOYSA-N
SMILES: NC1=CC2=NC3=CC(N)=CC=C3C=C2C=C1.Cl.Cl
Biological Activity: 3,6-Diaminoacridine dihydrochloride is a versatile acridine compound. 3,6-Diaminoacridine dihydrochloride exerts antibacterial activity by intercalating into bacterial DNA, interfering with replication and transcription, and inducing bacterial lysis. 3,6-Diaminoacridine dihydrochloride is an acridine dye and also a DNA intercalator[1][2][3].
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3,6-Diaminoacridine dihydrochloride | 3,6-Diaminoacridine dihydrochloride is a versatile acridine compound. 3,6-Diaminoacridine dihydrochloride exerts antibacterial activity by intercalating into bacterial DNA, interfering with replication and transcription, and inducing bacterial lysis. 3,6-Diaminoacridine dihydrochloride is an acridine dye and also a DNA intercalator. | |||||||||||||||||||||
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References
- [1]. Kubota Y, et al. Fluorescence decay studies of the DNA-3,6-diaminoacridine complexes. Biophys Chem. 1984;19(1):25-37. [Content Brief]
- [2]. Gamage SA, et al. Synthesis and in vitro evaluation of 9-anilino-3,6-diaminoacridines active against a multidrug-resistant strain of the malaria parasite Plasmodium falciparum. J Med Chem. 1994;37(10):1486-1494. [Content Brief]
- [3]. Sabolova D, et al. Proflavine/acriflavine derivatives with versatile biological activities. J Appl Toxicol. 2020;40(1):64-71. [Content Brief]
Keywords
