533883-77-1
533883-77-1
Chemical Structure
rel-Erteberel
Synonym(s): rel-LY500307
- CAS No.: 533883-77-1
- Formula:C18H18O3
- Molecular Weight:282.33
InChIKey: XIESSJVMWNJCGZ-HDMKZQKVSA-N
SMILES: OC1=CC=C2O[C@H](C3=CC=C(C=C3)O)[C@@](CCC4)([H])[C@@]4([H])C2=C1
Biological Activity: rel-Erteberel is rel isomer of Erteberel (HY-18295). Erteberel is a potent and selective estrogen receptor beta (ERβ) agonist with Ki and EC50 of 1.54 nM and 3.61 nM, respectively. Erteberel has anti-tumor activities[1][2].
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rel-Erteberel | rel-Erteberel is rel isomer of Erteberel (HY-18295). Erteberel is a potent and selective estrogen receptor beta (ERβ) agonist with Ki and EC50 of 1.54 nM and 3.61 nM, respectively. Erteberel has anti-tumor activities. | |||||||||||||||||||||
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References
- [1]. Zhao L, et al. Pharmacological activation of estrogen receptor beta augments innate immunity to suppress cancer metastasis. Proc Natl Acad Sci U S A. 2018 Apr 17;115(16):E3673-E3681. [Content Brief]
- [2]. Sareddy GR, et al. Selective Estrogen Receptor β Agonist LY500307 as a Novel Therapeutic Agent for Glioblastoma. Sci Rep. 2016 Apr 29;6:24185. [Content Brief]
Keywords
