53772-85-3
Chemical Structure
trans-Flupentixol
Synonym(s): trans-Flupenthixol
- CAS No.: 53772-85-3
- Formula:C23H25F3N2OS
- Molecular Weight:434.52
IUPAC Name: (E)-2-(4-(3-(2-(trifluoromethyl)-9H-thioxanthen-9-ylidene)propyl)piperazin-1-yl)ethan-1-ol
InChIKey: NJMYODHXAKYRHW-BLLMUTORSA-N
SMILES: C(\CCN1CCN(CCO)CC1)=C\2/C=3C(SC=4C2=CC=CC4)=CC=C(C(F)(F)F)C3
Biological Activity: trans-Flupentixol (trans-Flupenthixol) is an isomer of the orally active cis-flupenthixol (HY-184837) and Flupenthixol (HY-15856A) that modulates NMDA receptor subunits. trans-Flupentixol regulates the mRNA expression levels of NMDAR1 and NMDAR2A-D. trans-Flupentixol is used in schizophrenia-related research[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
trans-Flupentixol | trans-Flupentixol (trans-Flupenthixol) is an isomer of the orally active cis-flupenthixol (HY-184837) and Flupenthixol (HY-15856A) that modulates NMDA receptor subunits. trans-Flupentixol regulates the mRNA expression levels of NMDAR1 and NMDAR2A-D. trans-Flupentixol is used in schizophrenia-related research. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Chen AC, et al. Gene expression studies of mRNAs encoding the NMDA receptor subunits NMDAR1, NMDAR2A, NMDAR2B, NMDAR2C, and NMDAR2D following long-term treatment with cis-and trans-flupenthixol as a model for understanding the mode of action of schizophrenia drug treatment. Brain research. Molecular brain research. 1998 Feb;54(1):92-100.
- [2]. Murugaiah K, et al. Alterations in different populations of striatal dopamine receptors produced by 18 months continuous administration of cis- or trans-flupenthixol to rats. Neuropharmacology. 1984 Jun;23(6):599-609.
- [3]. Jensen TS, et al. Effects of an intrathecal dopamine agonist, apomorphine, on thermal and chemical evoked noxious responses in rats. Brain research. 1984 Apr 02;296(2):285-93.
