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Cat. No.: HY-15856D

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trans-Flupentixol

Name: trans-Flupentixol
Brand: MedChemExpress
SKU: HY-15856D
Availability: PreOrder

(Synonyms: trans-Flupenthixol)

trans-Flupentixol (trans-Flupenthixol) is an isomer of the orally active cis-flupenthixol (HY-184837) and Flupenthixol (HY-15856A) that modulates NMDA receptor subunits. trans-Flupentixol regulates the mRNA expression levels of NMDAR1 and NMDAR2A-D. trans-Flupentixol is used in schizophrenia-related research.

For research use only. We do not sell to patients.

CAS No.: 53772-85-3
Formula: C₂₃H₂₅F₃N₂OS
Molecular Weight:434.52

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

trans-Flupentixol Chemical Structure

CAS No.: 53772-85-3

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Biological Activity
- Description
- In Vivo
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Biological Activity

Description

In Vivo

trans-Flupentixol (trans-isomer) (0.2 mg/kg/day; p.o.; for 24 weeks) induces region-specific and time-dependent alterations in NMDA receptor subunit mRNA expression in rat brain, with the most consistent effect being the downregulation of NMDAR1 mRNA in multiple brain regions^[1].
trans-Flupentixol (trans-Flupenthixol) (0.9-1.2 mg/kg per day; p.o.; continuous; 18 months) fails to alter striatal D-2 receptor number or affinity, [³H]NPA agonist binding sites, [³H]piflutixol binding, or dopamine-stimulated adenylate cyclase activity, nor does it potentiate Apomorphine (HY-12723)-induced stereotyped behavior in rats^[2].
trans-Flupentixol (trans-Flupenthixol) (20-60 nmol; 10 min, intrathecal administration) does not alter baseline tail-flick and hot-plate response latencies in rats prior to Apomorphine administration^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Sprague-Dawley (adult male, 225-250 g)^[1]
Dosage:

0.2 mg/kg/day
Administration:

p.o.; continuous; up to 24 weeks
Result:

Altered NMDA‑receptor‑subunit mRNA abundances across multiple rat brain regions following 24‑week treatment.
Decreased NMDAR1 and NMDAR2A mRNA in frontal cortex, cerebellum, subcortical structures and parietal cortex.
Exhibited biphasic responses for NMDAR2B, NMDAR2C and NMDAR2D with early‑phase mRNA elevation at 2 weeks‑12 weeks and late‑phase mRNA suppression at 24 weeks
Diminished cerebellar NMDAR1 immunoreactivity at 24 weeks.

Chemical Information

CAS No. 53772-85-3
Molecular Weight 434.52
Formula C₂₃H₂₅F₃N₂OS
SMILES

C(\CCN1CCN(CCO)CC1)=C\2/C=3C(SC=4C2=CC=CC4)=CC=C(C(F)(F)F)C3
Synonyms

trans-Flupenthixol
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Chen AC, et al. Gene expression studies of mRNAs encoding the NMDA receptor subunits NMDAR1, NMDAR2A, NMDAR2B, NMDAR2C, and NMDAR2D following long-term treatment with cis-and trans-flupenthixol as a model for understanding the mode of action of schizophrenia drug treatment. Brain research. Molecular brain research. 1998 Feb;54(1):92-100.

[2]. Murugaiah K, et al. Alterations in different populations of striatal dopamine receptors produced by 18 months continuous administration of cis- or trans-flupenthixol to rats. Neuropharmacology. 1984 Jun;23(6):599-609.

[3]. Jensen TS, et al. Effects of an intrathecal dopamine agonist, apomorphine, on thermal and chemical evoked noxious responses in rats. Brain research. 1984 Apr 02;296(2):285-93.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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