545-84-6
Chemical Structure
(−)-Voacangarine
- CAS No.: 545-84-6
- Formula:C22H28N2O4
- Molecular Weight:384.47
IUPAC Name: methyl (6S,6aS,7S,9R,11S)-7-((S)-1-hydroxyethyl)-2-methoxy-7,8,9,10,12,13-hexahydro-5H-6,9-methanopyrido[1',2':1,2]azepino[4,5-b]indole-6(6aH)-carboxylate
InChIKey: OYMQKBZMKFJPMH-VJMPXSKLSA-N
SMILES: O=C([C@@]1([C@@]([C@@](C2)([H])[C@@H](O)C)([H])[N@@]3C[C@@]2([H])C1)C4=C(CC3)C5=CC(OC)=CC=C5N4)OC
Biological Activity: (−)-Voacangarine is an indole alkaloid, which exhibits cytotoxic effects against cancer cells HepG2, A375, MDA-MB-231, SH-SY5Y, and CT26 with IC50 of 5~20 mg/mL. (−)-Voacangarine inhibits the cultivation of Saccharomyces cerevisiae wildtype and repair-deficient mutants[1][2].
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(−)-Voacangarine | (−)-Voacangarine is an indole alkaloid, which exhibits cytotoxic effects against cancer cells HepG2, A375, MDA-MB-231, SH-SY5Y, and CT26 with IC50 of 5~20 mg/mL. (−)-Voacangarine inhibits the cultivation of Saccharomyces cerevisiae wildtype and repair-deficient mutants. | |||||||||||||||||||||
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Keywords
