548-90-3
Chemical Structure
Trichodesmine
- CAS No.: 548-90-3
- Formula:C18H27NO6
- Molecular Weight:353.41
IUPAC Name: (3R,4R,5R,8a1R,13aR)-4,5-dihydroxy-3-isopropyl-4,5-dimethyl-4,5,8,8a1,10,12,13,13a-octahydro-2H-[1,6]dioxacycloundecino[2,3,4-gh]pyrrolizine-2,6(3H)-dione
InChIKey: SOODLZHDDSGRKL-FOOXYVKASA-N
SMILES: O=C(O[C@]1([H])CCN2[C@]1([H])C(CO3)=CC2)[C@H](C(C)C)[C@@](C)(O)[C@@](C)(O)C3=O
Biological Activity: Trichodesmine is a dehydropyrrolizidine alkaloid. Trichodesmine can produces hepatotoxicty, pneumo- and neurotoxicity in vivo[1][2].
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Trichodesmine | Trichodesmine is a dehydropyrrolizidine alkaloid. Trichodesmine can produces hepatotoxicty, pneumo- and neurotoxicity in vivo. | |||||||||||||||||||||
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- [1]. Cooper RA, et, al. The relationship between reactivity of metabolites of pyrrolizidine alkaloids and extrahepatic toxicity. Proc West Pharmacol Soc. 1999;42:13-6. [Content Brief]
- [2]. Pessoa CRM, et, al. Pulmonary and hepatic lesions caused by the dehydropyrrolizidine alkaloid-producing plants Crotalaria juncea and Crotalaria retusa in donkeys. Toxicon. 2013 Sep;71:113-20. [Content Brief]
Keywords