548472-58-8
548472-58-8
Chemical Structure
Nutlin 1
- CAS No.: 548472-58-8
- Formula:C32H34Cl2N4O4
- Molecular Weight:609.54
IUPAC Name: 1-(4-((4R,5S)-4,5-bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-1-yl)ethan-1-one
InChIKey: IYDMGGPKSVWQRT-IHLOFXLRSA-N
SMILES: CC(N1CCN(CC1)C(N2[C@H]([C@H](N=C2C3=CC=C(C=C3OC(C)C)OC)C4=CC=C(C=C4)Cl)C5=CC=C(C=C5)Cl)=O)=O
Biological Activity: Nutlin 1, an antagonist of MDM2, activates a major cellular function of the p53 pathway, with an IC50 value of 0.26 μM[1].
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Nutlin 1 | Nutlin 1, an antagonist of MDM2, activates a major cellular function of the p53 pathway, with an IC50 value of 0.26 μM. | |||||||||||||||||||||
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References
Keywords
