55003-81-1
55003-81-1
Chemical Structure
CRBN ligand-9
- CAS No.: 55003-81-1
- Formula:C13H9N3O6
- Molecular Weight:303.23
IUPAC Name: 2-(2,6-dioxopiperidin-3-yl)-5-nitroisoindoline-1,3-dione
InChIKey: MYPNWKPZEHVONN-UHFFFAOYSA-N
SMILES: O=C1NC(CCC1N2C(C3=CC=C(C=C3C2=O)[N+](=O)[O-])=O)=O
Biological Activity: CRBN ligand-9 (Compound 4d) is a CRBN ligand (Ki: 8.9 μM). CRBN ligand-9 can be used for synthesis of PROTACs[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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CRBN ligand-9 | 98.0% | CRBN ligand-9 (Compound 4d) is a CRBN ligand (Ki: 8.9 μM). CRBN ligand-9 can be used for synthesis of PROTACs. | ||||||||||||||||||||
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References
- [1]. Heim C,et al. De-Novo Design of Cereblon (CRBN) Effectors Guided by Natural Hydrolysis Products of Thalidomide Derivatives. J Med Chem. 2019 Jul 25;62(14):6615-6629. [Content Brief]
- [2]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. [Content Brief]
Keywords
