CRBN ligand-9
Based on 1 Customer Validation
CRBN ligand-9 (Compound 4d) is a CRBN ligand (Ki: 8.9 μM). CRBN ligand-9 can be used for synthesis of PROTACs.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté: 98.0%
- CAS No.: 55003-81-1
- Formule: C13H9N3O6
- Masse moléculaire:303.23
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
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Cereblon |
Chemical Information
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CAS No. 55003-81-1
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Appearance Solid
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Masse moléculaire 303.23
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Formule C13H9N3O6
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Color Off-white to gray
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SMILES
O=C1NC(CCC1N2C(C3=CC=C(C=C3C2=O)[N+](=O)[O-])=O)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvant et solubilité
DMSO : ≥ 100 mg/mL (329.78 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (273 KB)
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SDS (392 KB)
- English - EN (392 KB)
- Français - FR (392 KB)
- Deutsch - DE (392 KB)
- Norwegian - NO (392 KB)
- Español - ES (392 KB)
- Swedish - SV (392 KB)
- Italian - IT (392 KB)
- Korean - KR (392 KB)
- Portuguese - PT (392 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Heim C,et al. De-Novo Design of Cereblon (CRBN) Effectors Guided by Natural Hydrolysis Products of Thalidomide Derivatives. J Med Chem. 2019 Jul 25;62(14):6615-6629. [Content Brief]
[2]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.2978 mL | 16.4891 mL | 32.9783 mL | 82.4457 mL |
| 5 mM | 0.6596 mL | 3.2978 mL | 6.5957 mL | 16.4891 mL | |
| 10 mM | 0.3298 mL | 1.6489 mL | 3.2978 mL | 8.2446 mL | |
| 15 mM | 0.2199 mL | 1.0993 mL | 2.1986 mL | 5.4964 mL | |
| 20 mM | 0.1649 mL | 0.8245 mL | 1.6489 mL | 4.1223 mL | |
| 25 mM | 0.1319 mL | 0.6596 mL | 1.3191 mL | 3.2978 mL | |
| 30 mM | 0.1099 mL | 0.5496 mL | 1.0993 mL | 2.7482 mL | |
| 40 mM | 0.0824 mL | 0.4122 mL | 0.8245 mL | 2.0611 mL | |
| 50 mM | 0.0660 mL | 0.3298 mL | 0.6596 mL | 1.6489 mL | |
| 60 mM | 0.0550 mL | 0.2748 mL | 0.5496 mL | 1.3741 mL | |
| 80 mM | 0.0412 mL | 0.2061 mL | 0.4122 mL | 1.0306 mL | |
| 100 mM | 0.0330 mL | 0.1649 mL | 0.3298 mL | 0.8245 mL |
CRBN ligand-9 Related Classifications
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