555-62-4
Chemical Structure
NSD 1034
- CAS No.: 555-62-4
- Formula:C8H12N2O
- Molecular Weight:152.19
IUPAC Name: 3-((1-methylhydrazinyl)methyl)phenol
InChIKey: BJJDPKGXTMVSKI-UHFFFAOYSA-N
SMILES: OC1=CC=CC(CN(C)N)=C1
Biological Activity: NSD 1034 is a potent inhibitor of aromatic L-amino acid decarboxylase (AADC) and tyrosine aminotransferase (TAT), with IC50 values of 0.32 μM and 80 μM, respectively. NSD 1034 increases dopamine synthesis and release by inhibiting AADC and TAT, and stimulating tyrosine hydroxylase in dopaminergic neurons via calcium influx in a classical dopamine receptor-independent manner. NSD 1034 is used in studies of Parkinson's disease and sleep disorders[1][2][3].
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NSD 1034 | NSD 1034 is a potent inhibitor of aromatic L-amino acid decarboxylase (AADC) and tyrosine aminotransferase (TAT), with IC50 values of 0.32 μM and 80 μM, respectively. NSD 1034 increases dopamine synthesis and release by inhibiting AADC and TAT, and stimulating tyrosine hydroxylase in dopaminergic neurons via calcium influx in a classical dopamine receptor-independent manner. NSD 1034 is used in studies of Parkinson's disease and sleep disorders. | |||||||||||||||||||||
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References
- [1]. Nissbrandt H, et al. NSD 1034: an amino acid decarboxylase inhibitor with a stimulatory action on dopamine synthesis not mediated by classical dopamine receptors. Naunyn-Schmiedeberg's archives of pharmacology. 1988 Aug;338(2):148-61.
- [2]. Dyck LE, et al. Effect of decarboxylase inhibitors on brain p-tyrosine levels. Biochemical pharmacology. 1987 Apr 15;36(8):1373-6.
- [3]. Juorio AV, et al. The effect of some decarboxylase inhibitors on striatal tyramines in the mouse. Neuropharmacology. 1983 Jan;22(1):71-3.
